Search results for " phenylalanine"

showing 5 items of 5 documents

Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma.

2019

Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity of GBM and to correlate it with the clinical characteristics of the patients. For that purpose, we analyzed the status of EGFR and the somatic copy number alterations (CNAs) of a set of tumor suppressor genes and oncogenes. Thus, we found GBMs with high level of EGFR amplification, low level and with no EGFR amplification. Highly amplified tumors showed histological features of…

0301 basic medicineMaleCancer ResearchBiopsyL-amp GB EGFR-low amplified glioblastomamedicine.disease_causewt wildtypeMYBPC3 myosin-binding protein C0302 clinical medicineHIC1 hypermethylated in cancer 1Gene duplicationIn Situ Hybridization FluorescenceIDH2 isocitrate dehydrogenase 2MutationRB-pat RB signaling pathwayEGFRvIII epidermal growth factor receptor variant number IIIPAH phenylalanine hydroxylaseGBM glioblastoma IDH-wildtype (glioblastoma multiforme primary glioblastoma).ANOVA ANalysis Of VArianceN-amp GB EGFR-no amplified glioblastomaMiddle AgedCDKN2A cyclin-dependent kinase inhibitor 2Alcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensPrognosisPrimary tumorImmunohistochemistryH-amp GB EGFR-high amplified glioblastomaErbB ReceptorsTKR-pat tyrosine-kinase receptors signaling pathway030220 oncology & carcinogenesisDisease ProgressionCDK6 cyclin-dependent kinase 6CDH1 Cadherin 1FemaleCREM cAMP response element modulatorIHC immunohistochemistryAdultOriginal articleDNA Copy Number VariationsCDKN1B cyclin-dependent kinase inhibitor 1BBiologyRARB retinoic acid receptor betaCNS central nervous systemlcsh:RC254-282IDH1 isocitrate dehydrogenase 1BCL2 B-cell cll/ lymphoma 2CNAs copy number algerationsWHO World Health Organization03 medical and health sciencesYoung Adultp53-pat p53 signaling pathwaymedicineBiomarkers TumorTMA tissue microarrayPTENHumansProtein kinase BPI3K/AKT/mTOR pathwaySurvival analysisAgedGenetic heterogeneityGene AmplificationGFAP glial fibrillary acidic proteinMLPA multiplex ligation-dependent probe amplificationmedicine.diseaseFISH fluorescence in situ hibridizationSurvival AnalysisCDKN2B cyclin-dependent kinase inhibitor 2BPTEN phosphatase and tensin homologEGFR epidermal growth factor receptorCNV-load load of copy number variations030104 developmental biologyMutationPARK2 parkinCancer researchbiology.proteinTCGA The Cancer Genome AtlasLARGE1 acetylglucosaminyltransferase-like protein 1GlioblastomaCHD7 Chromodomain Helicase DNA Binding Protein 7DAPI 4′6-diamidino-2-phenylindoleNeoplasia (New York, N.Y.)
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Low-Q peak in X-ray patterns of choline-phenylalanine and homophenylalanine: a combined effect of chain and stacking

2016

Abstract In this contribution we report for the first time the X-ray patterns of choline-phenylalanine and choline-homophenylalanine ionic liquids. The presence of a low Q peak in both systems is another evidence that a long alkyl chain is not always needed to establish a nanodomain segregation in the liquid sufficient to be revealed by the diffraction experiment. These new data are compared with the diffraction patterns and the theoretical calculations of other choline-aminoacid ionic liquids recently reported. A significant role might be played by the stacking interactions between aromatic rings.

DiffractionChemical substancePhenylalanineStackingGeneral Physics and AstronomyPhenylalanine02 engineering and technologyIonic liquid010402 general chemistry01 natural sciencesCholinePhysics and Astronomy (all)chemistry.chemical_compoundAminoacidSettore CHIM/02Organic chemistryPhysical and Theoretical ChemistryAlkylcholine-amino acid ionic liquids EDXD; ion pairs; pre-peak; renewable materialschemistry.chemical_classificationSmall-angle X-ray scatteringSAXS; Choline; Phenylalanine; Aminoacids; Ionic liquidsAromaticitySAXS021001 nanoscience & nanotechnologyIonic liquids0104 chemical sciencesCrystallographychemistryIonic liquid0210 nano-technologyAminoacids
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Conformational properties of N′,N′-dimethylamides of N-acetyldehydroalanine and N-acetyl-(Z)-dehydrophenylalanine

2001

Conformational preferences of Ac-deltaAla-NMe2 and Ac-(Z)-deltaPhe-NMe2 were studied and compared with those of their monomethyl counterparts as well as with those of their saturated analogues. X-Ray data and energy calculations revealed a highly conservative conformation of the dehydro dimethylamides, which is located in a high-energy region of the Ramachandran map.

N¢-dimethylamidesaalanine and phenylalaninederivativesN¢b-dehydroamino acidsGeneral Biochemistry Genetics and Molecular BiologyX-ray crystallographytheoretical calculations
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Genetic diversity within the R408W phenylketonuria mutation lineages in Europe

2003

The R408W phenylketonuria mutation in Europe has arisen by recurrent mutation in the human phenylalanine hydroxylase (PAH) locus and is associated with two major PAH haplotypes. R408W-2.3 exhibits a west-to-east cline of relative frequency reaching its maximum in the Balto–Slavic region, while R408W-1.8 exhibits an east-to-west cline peaking in Connacht, the most westerly province of Ireland. Spatial autocorrelation analysis has demonstrated that the R408W-2.3 cline, like that of R408W-1.8, is consistent with a pattern likely to have been established by human dispersal. Genetic diversity within wild-type and R408W chromosomes in Europe was assessed through variable number tandem repeat (VNT…

Population geneticsEurope; PAH; Phenylalanine hydroxylase; Phenylketonuria; PKU; Population genetics; STR; VNTR;VNTRPopulation geneticsLocus (genetics)Minisatellite RepeatsBiologyArginineSTRPhenylketonuriasGeneticsHumansPhenylketonuriaGenetic TestingAlleleGenetics (clinical)GeneticsGenetic diversityPhenylalanine hydroxylaseHaplotypeTryptophanGenetic VariationCline (biology)PAHFounder EffectEuropeVariable number tandem repeatAmino Acid SubstitutionPKUMutationMicrosatelliteMicrosatellite Repeats
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METABOLIC PROMOTERS AFFECT YIELD AND FRUIT QUALITY OF 'SANFILIPPARA' AND 'TRABIA' LOQUAT

2015

Preliminary field trials with foliar applications of phenylalanine, methionine, oxylipins and sugars have shown improvements of external color, sugar content and uniformity of maturation in grapes, pome fruits, tomatoes and melons. In this study, we hypothesized that similar improvements could be obtained both in fruit of ‘Trabia’ and ‘Sanfilippara’ loquat (Eriobotrya japonica Lindl.) with applications of a commercial formulate called Sunred (Biolchim, Bologna, Italy) and containing various concentrations of the above metabolic promoters. The study was conducted on 12 ‘Sanfilippara’ and 12 ‘Trabia’ adult loquat trees grown in an orchard near Palermo, Italy. Half of the trees…

biologyfood and beveragesTitratable acidEriobotryaHorticulturebiology.organism_classificationJaponicaSettore AGR/03 - Arboricoltura Generale E Coltivazioni ArboreeHorticulturePomeYield (wine)CultivarOrchardEriobotra japonica fruit ripening methionine oxylipins peel color phenylalanineSugarActa Horticulturae
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